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Understanding the effects of personal
lubricants on sperm function
Many studies have found a deleterious effect of personal lubricants on sperm function such as motility, including a decreased ability of sperm to penetrate cervical mucus after exposure to lubricants.
In fact, several studies show that: KY Jelly, Astroglide and Replens killed SPERM EQUIVALENTLY TO CONTRACEPTIVE JELLIES.
A recent abstract (View Abstract) also shows an actual and severe decline in the ability of embryos to form in vitro (using a bovine model) when the sperm are exposed to the leading personal lubricant product.
This is particularly important in view of the fact that TTC couples report an increased incidence of vaginal dryness, due to stress and fertility medications. Most TTcers (>70%) have not spoken with their physician about vaginal dryness, and unfortunately, some of those that do are referred to sperm toxic products.
In contrast, Pre~Seed, a new product developed to relieve vaginal dryness while providing an optimal environment for sperm, did not interfere with sperm function or embryo development in studies done to date as cited below.
1. Anderson L, Lewis SE, McClure N. The effects of coital lubricants on sperm motility in vitro. Human Reproduction 1998; 13:3351-3356.
2. Frishman GN, LucianoAA, Maier DB. Evaluation of Astroglide, a new vaginal lubricant: effects of length of exposure and concentration on sperm motility. Fertil and Steril 1992; 58: 630-632.
3. Kutteh WH, Choe CH, Ritter JO, et al. Vaginal lubricants for the infertile couple: effect on sperm activity. Int J Fertil Meno Stud 1996; 41:400-404.
4. Miller B, Klein TA, Opsahl MS. The effect of surgical lubricant on in vivo sperm penetration of cervical mucus. Fertil Steril 1994; 6:1171-1173.
5. Tagatz GE, Okagake T, Sciarra JJ. The effect of vaginal lubricants on sperm motility and viability in vitro. Am. J. Obstet. Gynecol. 1972; 113:88-90.
6. Tulandi T, Plouffe L Jr, McInnes RA. Effect of saliva on sperm motility and activity. Fertil and Steril 1982; 38: 721-723.
7. Tulandi T, McInnes RA. Vaginal lubricants: effect of glycerin and egg white on sperm motility and progression in vitro. Fertil Steril 1984; 41:151-153.
8. Ozgur K, Franken DR, Kaskar K, Gabriel LK, Kruger TF. The influence of a mineral oil overlay on the zona pellucida binding potential of human spermatozoa. Andrologia. 1995; 27:155-159.
9. Wright RW, Ellington JE. Effects of personal lubricants on in vitro fertilization and embryo development. American Society Andrology, March 2003: phoenix, AZ. (View Abstract).
10. Ellington, JE Short RA, Schimmels J. Effect of new intimate moisturizer on sperm motility. American Society Andrology. March 2003, Phoenix, AZ. (View Abstract).
11. Ellington JE, Short RA. Prevalence of vaginal dryness in trying to conceive couples. Pacific Coast Reproductive Society Meeting April, 2003. Rancho Mirage, CA (View Abstract).
12. Ellington JE, Schimmels J. The effects of vaginal lubricants on computer assisted sperm analysis parameters associated with cervical mucus penetration. Submitted to American Society of Reproductive Medicine, October 2004 (View Abstract).
13. A. Agarwal, T. M. Said, K. Seifarth, D. P. Evenson, R. A. Short. Changes in Sperm Motility and Chromatin Integrity Following Contact with Vaginal Lubricants. Submitted to American Society of Reproductive Medicine, April 2005 (View Abstract).
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